Kuramoto M
Nihon Sanka Fujinka Gakkai Zasshi. 1981 Nov;33(11):1897-1904.
The circulating immune complexes in pregnancy sera have been thought to act immunosuppressively to maternal lymphoid system, and to be one of the cause of toxemia of pregnancy. We detected circulating immune complexes in human pregnancy sera using Raji cell test and polyethylene glycol precipitation. We evaluated the correlation between the titers of immune complexes and inhibition rate of lymphocyte blastogenic responses to PHA as well as Con A. There were significant positive correlation (p less than 0.01, p less than 0.02, respectively). Moreover, we also evaluate the correlation between immune complexes and clinical symptoms of toxemia of pregnancy in items of Gestosis Index. There was no significant correlation at the time of sampling, but highly significant correlation was obtained at the time of admission for labor. The differences of Gestosis Indexes at the time of blood sampling and admission for labor were highly significant in the group of high immune complex titer. The cases of toxemia of pregnancy were found that immune complex increased before the symptoms of toxemia of pregnancy appeared. These results suggest that circulating immune complexes in pregnancy have the role of immunosuppression and act as one of the cause of toxemia of pregnancy.
妊娠血清中的循环免疫复合物被认为对母体淋巴系统具有免疫抑制作用，并且是妊娠中毒症的病因之一。我们使用Raji细胞试验和聚乙二醇沉淀法检测了人类妊娠血清中的循环免疫复合物。我们评估了免疫复合物滴度与淋巴细胞对PHA以及Con A的增殖反应抑制率之间的相关性。两者之间存在显著正相关（分别为p<0.01，p<0.02）。此外，我们还从妊娠中毒症指数方面评估了免疫复合物与妊娠中毒症临床症状之间的相关性。在采样时无显著相关性，但在入院分娩时获得了高度显著的相关性。在高免疫复合物滴度组中，采血时和入院分娩时的妊娠中毒症指数差异非常显著。发现妊娠中毒症病例在妊娠中毒症症状出现之前免疫复合物增加。这些结果表明，妊娠中的循环免疫复合物具有免疫抑制作用，并作为妊娠中毒症的病因之一起作用。
