Moritoki H, Kanbe T, Maruoka M, Ohara M, Ishida Y
J Pharmacol Exp Ther. 1978 Feb;204(2):343-50.
The inhibition actions of adenosine and adenine nucleotides, such as ATP, AMP and cyclic AMP, on contractions of guinea-pig from ileum induced by transmural stimulation were potentiated by dipyridamole, whereas those of inosine, morphine and tetrodotoxin were not affected. Tritium activity, accumulated during incubation of the ileal segments with [3H]adenosine, was reduced by dipyridamole. The adenosine added was degraded to inosine and then hypoxanthine during incubation, with the ileal segments, thereby restoring the twitch response of the ileal segments. In the presence of dipyridamole, the degradation of adenosine and the recovery of the twitch response was retarded. Thus, dipyridamole may potentiate the inhibitory actions of adenosine and adenine nucleotides on the twitch response of the ileum by inhibiting both the accumulation and the degradation of adenosine.
双嘧达莫可增强腺苷及腺嘌呤核苷酸（如三磷酸腺苷、一磷酸腺苷和环磷酸腺苷）对豚鼠回肠经壁刺激诱导收缩的抑制作用，而肌苷、吗啡和河豚毒素的抑制作用则不受影响。双嘧达莫可降低回肠段与[3H]腺苷孵育期间积累的氚活性。添加的腺苷在与回肠段孵育期间降解为肌苷，然后再降解为次黄嘌呤，从而恢复回肠段的抽搐反应。在双嘧达莫存在的情况下，腺苷的降解及抽搐反应的恢复均受到抑制。因此，双嘧达莫可能通过抑制腺苷的积累和降解来增强腺苷及腺嘌呤核苷酸对回肠抽搐反应的抑制作用。
