Poli E, Coruzzi G
Acta Biomed Ateneo Parmense. 1982;53(3):117-9.
A new synthetic prostaglandin, namely the 15 alpha, 16 (R), 16-methyl-16-methoxy PGE1 (compound marked MDL 646), endowed with a potent antiulcer activity, was studied for its effects on gastroesophageal motility of the rat in comparison with natural PGE1. Surprisingly enough, the two compounds were found to differ not only from a quantitative but also from a qualitative point of view. In fact, the natural PGE1 had, as expected, a relaxant effect on all the preparations examined except the rat fundus which is known to be contracted by all the different types of prostaglandins; conversely its synthetic analogue (MDL 646) showed a remarkable stimulatory effect on both "in vitro" and "in vivo" preparations. It is obvious that if these observations will be confirmed in other animal species, they could have a remarkable practical interest.
一种新的合成前列腺素，即15α，16（R），16-甲基-16-甲氧基PGE1（标记为MDL 646的化合物），具有强大的抗溃疡活性，与天然PGE1相比，研究了其对大鼠胃食管运动的影响。令人惊讶的是，发现这两种化合物不仅在数量上而且在质量上都有所不同。事实上，天然PGE1正如预期的那样，对所有检查的制剂都有松弛作用，但已知所有不同类型的前列腺素都会使大鼠胃底收缩；相反，其合成类似物（MDL 646）对“体外”和“体内”制剂均显示出显著的刺激作用。显然，如果这些观察结果在其他动物物种中得到证实，它们可能具有显著的实际意义。
