Mehta P, Mehta J, Hay D
Prostaglandins Leukot Med. 1982 Nov;9(5):539-48. doi: 10.1016/0262-1746(82)90035-x.
Recent description of thromboxane (TXA2) synthesis by endothelial cells in addition to prostacyclin (PGI2) has stimulated interest in the significance of TXA2 generation by vessel walls. We studied TXA2 and PGI2 release from human umbilical veins with intact and continuous endothelium. Resting TXB2 (stable metabolite of TXA2) concentrations in umbilical vein effluent (mean 0.45 +/- 0.07 ng/ml) were lower than those of 6-keto-PGF1 alpha (stable metabolite of PGI2) (mean 92 +/- 26 ng/ml). Following mechanical trauma to the umbilical veins with a balloon catheter, documented by adherence of indium111-labeled platelets, both TXA2 and PGI2 increased in the venous effluent. Increase in TXB2 (65%) was less than that in 6-keto-PGF1 alpha (199%). These data show that a) human vessel walls generate both TXA2 and PGI2, b) both TXA2 and PGI2 increase following mechanical trauma, the former less than the latter. Vessel wall TXA2 generation may become pathologically relevant in conditions of decreased PGI2 generation.
除前列环素（PGI2）外，内皮细胞合成血栓素（TXA2）的最新描述引发了人们对血管壁生成TXA2意义的兴趣。我们研究了具有完整连续内皮的人脐静脉中TXA2和PGI2的释放情况。脐静脉流出液中静息TXB2（TXA2的稳定代谢产物）浓度（平均0.45±0.07纳克/毫升）低于6-酮-PGF1α（PGI2的稳定代谢产物）浓度（平均92±26纳克/毫升）。在用球囊导管对脐静脉造成机械损伤后，通过铟111标记血小板的黏附证明，静脉流出液中TXA2和PGI2均增加。TXB2的增加（65%）小于6-酮-PGF1α的增加（199%）。这些数据表明：a）人体血管壁可生成TXA2和PGI2；b）机械损伤后TXA2和PGI2均增加，前者增加幅度小于后者。在PGI2生成减少的情况下，血管壁TXA2的生成可能具有病理相关性。
