不同量的花生四烯酸对血管壁生成前列环素（PGI2）和血栓素A2（TXA2）的影响。

Effect of different amounts of arachidonic acid on vessel wall-generated PGI2 and TXA2.

作者信息

Mehta J, Mehta P, Ostrowski N

出版信息

Prostaglandins Leukot Med. 1983 Nov;12(3):253-9. doi: 10.1016/0262-1746(83)90003-3.

PMID:6419235

Abstract

It has been suggested that low concentrations of AA may have vasoprotective and high concentrations vaso-damaging effects. To relate these effects to vascular generation of PGI2 and TXA2, we incubated human umbilical vein rings with AA (0, 0.01, 0.1, 1 and 2 mM) and examined the supernates for 6-keto-PGF1 alpha and TXB2. Low concentrations of AA (0.01 and 0.1 mM) caused preferential and maximal PGI2 release, whereas higher concentrations (1 and 2 mM) resulted in marked and preferential increase in TXA2 release. Disequilibrium in vascular PGI2 and TXA2 release towards the latter may relate to vaso-damaging effects of high concentrations of AA.

摘要

有人提出，低浓度的花生四烯酸（AA）可能具有血管保护作用，而高浓度则具有血管损伤作用。为了将这些作用与血管中前列环素（PGI2）和血栓素A2（TXA2）的生成联系起来，我们将人脐静脉环与AA（0、0.01、0.1、1和2 mM）一起孵育，并检测上清液中的6-酮-前列腺素F1α（6-keto-PGF1α）和血栓素B2（TXB2）。低浓度的AA（0.01和0.1 mM）导致PGI2优先且最大程度地释放，而较高浓度（1和2 mM）则导致TXA2释放显著且优先增加。血管中PGI2和TXA2释放向后者的失衡可能与高浓度AA的血管损伤作用有关。