噬菌体T4中32、41、44、45和62基因的琥珀突变抑制型的诱变和抗诱变表型
Mutator and antimutator phenotypes of suppressed amber mutants in genes 32, 41, 44, 45, and 62 in bacteriophage T4.
作者信息
Watanabe S M, Goodman M F
出版信息
J Virol. 1978 Jan;25(1):73-7. doi: 10.1128/JVI.25.1.73-77.1978.
Abstract
Bacteriophage T4 genes 32, 41, 44, 45, 56, and 62 are essential to DNA replication. Amber mutants (suppressed by su+1, su+2, or su+3 bacteria) in these genes were examined for any mutator or antimutator effects on the reversion of a transition mutation. In every case except for mutations in gene 56, elevated or lowered error frequencies were observed. These results indicate the importance of all of the replicative proteins in the determination of error frequency.
摘要
噬菌体T4的基因32、41、44、45、56和62对DNA复制至关重要。对这些基因中的琥珀突变体（由su+1、su+2或su+3细菌抑制）进行了检测，以观察其对转换突变回复的任何诱变或抗诱变作用。除基因56中的突变外，在每种情况下均观察到错误频率升高或降低。这些结果表明所有复制蛋白在错误频率测定中的重要性。
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Mutator and antimutator phenotypes of suppressed amber mutants in genes 32, 41, 44, 45, and 62 in bacteriophage T4.噬菌体T4中32、41、44、45和62基因的琥珀突变抑制型的诱变和抗诱变表型
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本文引用的文献
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Proc Natl Acad Sci U S A. 1962 Apr 15;48(4):532-46. doi: 10.1073/pnas.48.4.532.
2
Mutagenic DNA polymerase.诱变DNA聚合酶
Biochem Biophys Res Commun. 1965 Oct 8;21(1):6-8. doi: 10.1016/0006-291x(65)90417-1.
3
T4 bacteriophage gene 32: a structural protein in the replication and recombination of DNA.T4噬菌体基因32：DNA复制与重组中的一种结构蛋白。
Nature. 1970 Sep 26;227(5265):1313-8. doi: 10.1038/2271313a0.
4
Antimutagenic DNA polymerases of bacteriophage T4.噬菌体T4的抗诱变DNA聚合酶
Cold Spring Harb Symp Quant Biol. 1968;33:339-44. doi: 10.1101/sqb.1968.033.01.039.
5
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Nature. 1969 Mar 22;221(5186):1128-32.
6
Stimulation of T4 bacteriophage DNA polymerase by the protein product of T4 gene 32.T4基因32的蛋白质产物对T4噬菌体DNA聚合酶的刺激作用。
J Mol Biol. 1971 Nov 28;62(1):39-52. doi: 10.1016/0022-2836(71)90129-x.
7
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J Virol. 1971 Apr;7(4):460-6. doi: 10.1128/JVI.7.4.460-466.1971.
8
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Genetics. 1973 Apr;73:Suppl 73:45-64.
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J Virol. 1973 Jul;12(1):199-201. doi: 10.1128/JVI.12.1.199-201.1973.
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