Kobets N S, Piruzian E S, Alikhanian S I
Genetika. 1976;12(9):79-85.
The substitution of tester mutant ri31 (fs-type) for transition mutants rUV30 and rUV48 allowed to reveal new mutator alleles of DNA polymerase gene of phage T4. In these conditions about 70% alleles of this gene were found to be mutators. Unlike experiments carried out with mutant-tester ri31, in experiments with mutants rUV30 and rUV48 the presence of mutator alleles in gene 32 was demonstrated. The transition pathway AT leads to GC is the preferential direction of the mutation alteration under the action of suppressed amber alleles of genes 43 and 32. The data obtained suggest allele specificity of the mutator effect in bacteriophage T4.
用测试突变体ri31（移码型）替代转换突变体rUV30和rUV48，使得能够揭示噬菌体T4 DNA聚合酶基因的新的诱变等位基因。在这些条件下，发现该基因约70%的等位基因为诱变基因。与用突变测试体ri31进行的实验不同，在用突变体rUV30和rUV48进行的实验中，证明了基因32中存在诱变等位基因。在基因43和32的琥珀突变抑制等位基因作用下，AT到GC的转换途径是突变改变的优先方向。所获得的数据表明噬菌体T4中诱变效应的等位基因特异性。
