Mizuno T, Ishizuya A
C R Seances Soc Biol Fil. 1982;176(4):580-4.
Electron microscopical studies demonstrated that the small intestinal endoderm of young avian embryos cultures in vitro in the presence or absence of mesenchyme can differentiate into an absorptive epithelium with the brush border, and that, in the absence of mesenchyme the brush border develops much earlier than in the presence of mesenchyme, but goblet cells do not appear and morphogenesis of villi does not occur. These results show that the intestinal mesenchyme controls the endodermal differentiation, though the undifferentiated endoderm possesses self-differentiation potency.
电子显微镜研究表明，在有或没有间充质存在的情况下体外培养的幼禽胚胎小肠内胚层可分化为具有刷状缘的吸收上皮，并且在没有间充质的情况下，刷状缘的发育比有间充质时要早得多，但杯状细胞不出现且绒毛的形态发生也不发生。这些结果表明，尽管未分化的内胚层具有自我分化能力，但肠间充质控制着内胚层的分化。
