Gaucher A, Raul P, Wiederkehr P, Pourel J, Bertrand A, Colomb J N, Ethgen D
Rev Rhum Mal Osteoartic. 1982 Nov;49(11):841-6.
Isotope investigation of reflex sympathetic dystrophy is not limited to an evaluation of bony up-take, it also includes examination of the early dynamic scintigraphy of the vessels. The late views of bone scans reflect, above all, the bone's affinity for phosphate complexes i.e. the degree of osteoblast activity. Generally, dystrophies, independent of their site, show increased locoregional uptake, often quite intense, which appears early in the course of the disease. This supports histopathological findings. There are several advantages in using the bone scan in the investigation of reflex dystrophy: early diagnosis before the development of radiological signs, precise evaluation of the local extension of the dystrophic process and detection of the incidence of multifocal forms, follow-up of the course of the disease, definition of new clinical forms: patchy algodystrophy partial, decalcifying dystrophy, sub-radiological dystrophy, the aetiology in certain sites (especially the hip). Early dynamic scans that dystrophy is accompanied by an increase in the vascular compartment and decreased circulatory flow, a sign of the local stage of the disease. There is also an increase of the interstitial compartment, greater than that of the vascular compartment, explaining the presence of edema. The pathophysiological information gained from dynamic studies is matched by the therapeutic information: evaluation, or even prediction, of the effect of a given drug (cortisone, calcitonin).
反射性交感神经营养不良的同位素研究并不局限于对骨摄取的评估，它还包括对血管早期动态闪烁显像的检查。骨扫描的晚期影像首先反映了骨骼对磷酸盐复合物的亲和力，即成骨细胞的活动程度。一般来说，营养不良无论其发生部位如何，都表现为局部摄取增加，通常相当强烈，且在疾病过程早期就会出现。这支持了组织病理学的发现。在反射性交感神经营养不良的研究中使用骨扫描有几个优点：在放射学征象出现之前进行早期诊断，精确评估营养不良过程的局部范围以及检测多灶性形式的发生率，对疾病进程进行随访，确定新的临床形式：斑片状痛性营养不良局部型、脱钙性营养不良、亚放射学营养不良，某些部位（尤其是髋部）的病因。早期动态扫描显示营养不良伴有血管腔增加和循环血流减少，这是疾病局部阶段的一个迹象。间质腔也有增加，且大于血管腔的增加，这解释了水肿的存在。从动态研究中获得的病理生理信息与治疗信息相匹配：评估甚至预测某种特定药物（皮质醇、降钙素）的效果。
