Schou M, Simonsen M
Tissue Antigens. 1982 Nov;20(5):320-6. doi: 10.1111/j.1399-0039.1982.tb02247.x.
MLR phenotypes of outbred and inbred chickens typing B13 of the major histocompatibility complex (MHC) of the chicken were compared. F1 hybrids of outbred and inbred B13 positive chickens were analysed in mixed lymphocyte culture (MLC). The intermediate strength responses of cells from B13 heterozygous outbred chickens stimulated by inbred B13 homozygous chicken cells were not due to minor variations of B encoded lymphocyte activating determinants (Lads). Nor were Lads encoded by genes unlinked to the B complex responsible for these reactions. In contrast, F1 anti-parental type reactions were observed, and these alone are probably responsible for the intermediate strength reactions so often seen in typing of heterozygous outbreds with homozygous typing cells.
比较了鸡主要组织相容性复合体（MHC）B13型远交群和近交群鸡的混合淋巴细胞反应（MLR）表型。对远交群和近交群B13阳性鸡的F1杂种进行了混合淋巴细胞培养（MLC）分析。来自B13杂合远交群鸡的细胞被近交群B13纯合鸡细胞刺激后的中等强度反应，并非由B编码的淋巴细胞激活决定簇（Lad）的微小变异所致。与B复合体不连锁的基因所编码的Lad也不是这些反应的原因。相反，观察到了F1抗亲本型反应，并且可能正是这些反应单独导致了在使用纯合分型细胞对杂合远交群进行分型时经常出现的中等强度反应。
