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鸡主要组织相容性复合体中重组基因型的同种免疫特性分析。

Analysis of the alloimmune properties of a recombinant genotype in the major histocompatibility complex of the chicken.

作者信息

Vilhelmová M, Miggiano V C, Pink J R, Hála K, Hartmanová J

出版信息

Eur J Immunol. 1977 Oct;7(10):674-9. doi: 10.1002/eji.1830071004.

DOI:10.1002/eji.1830071004
PMID:73463
Abstract

In a population of (CB X CC)F1 X WB hybrids, a chicken was found with a presumably recombinant haplotype, BR1, whose antigenic products detectable by hemagglutination contained determinants derived from both parental haplotypes, i.e. B1 (from CB) and B2 (from CC). This recombinant bird and its progeny from different crosses were tested by skin grafting, graft-vs.-host (GVH) and mixed lymphocyte reactions (MLR). The results define two regions of the B system, the B-F and the B-G. The B-F region determined serologically defined antigens, histocompatibility antigens, and controlled the GVH and MLR reactions, while the B-G region was responsible only for synthesis of serologically detectable antigens.

摘要

在(CB×CC)F1×WB杂种群体中,发现一只鸡具有可能的重组单倍型BR1,其通过血凝反应可检测到的抗原产物包含来自两个亲本单倍型的决定簇,即来自CB的B1和来自CC的B2。通过皮肤移植、移植物抗宿主(GVH)和混合淋巴细胞反应(MLR)对这只重组鸡及其不同杂交后代进行了检测。结果确定了B系统的两个区域,即B-F和B-G。B-F区域决定血清学定义的抗原、组织相容性抗原,并控制GVH和MLR反应,而B-G区域仅负责血清学可检测抗原的合成。

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Immunogenetics. 1981;14(5):393-401. doi: 10.1007/BF00373319.
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Genetics of Ia-like alloantigens in chickens and linkage with B major histocompatibility complex.鸡中Ia样同种异体抗原的遗传学及其与B主要组织相容性复合体的连锁关系。
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