Davis J W, Phillips P E, Yue K T, Lewis H D, Hartman C R
JAMA. 1978 Feb 20;239(8):732-4. doi: 10.1001/jama.239.8.732.
Using a turbidimetric technique, we determined 1.7 micrometer adenosine diphosphate--induced platelet aggregation and disaggregation at 37 degrees C in the platelet-rich plasmas of two groups of men with coronary artery disease. Eleven men were nondiabetic and 11 had adult-onset diabetes mellitus without retinopathy. There were no significant differences (P greater than .05) between diabetics and nondiabetics of the following variables: age, platelet count in platelet-rich plasma, first and second phases of platelet aggregation, maximum extent of aggregation, and percent disaggregation at three minutes after maximum aggregation occurred. Although the mean adenosine diphosphate--induced platelet aggregation in the platelet-rich plasmas of adult-onset diabetic men with coronary artery disease and no retinopathy was not enhanced, and the mean rate of disaggregation was not reduced, when compared with nondiabetic men with coronary artery disease or with healthy men; a slow rate of platelet disaggregation (less than 10%) occurred more frequently in the platelet-rich plasmas of men with coronary artery disease.
我们采用比浊法，在37℃下测定了两组冠心病男性患者富含血小板血浆中1.7微米二磷酸腺苷诱导的血小板聚集和解聚情况。11名男性无糖尿病，11名患有成年发病型糖尿病且无视网膜病变。在以下变量方面，糖尿病患者和非糖尿病患者之间无显著差异（P大于0.05）：年龄、富含血小板血浆中的血小板计数、血小板聚集的第一和第二阶段、最大聚集程度以及最大聚集发生后三分钟的解聚百分比。尽管与患有冠心病的非糖尿病男性或健康男性相比，患有冠心病且无视网膜病变的成年发病型糖尿病男性患者富含血小板血浆中二磷酸腺苷诱导的平均血小板聚集未增强，平均解聚速率也未降低；但在冠心病男性患者的富含血小板血浆中，血小板解聚缓慢（低于10%）的情况更频繁发生。
