Fehér T, Bodrogi L, Vallent K, Ribai Z
Endokrinologie. 1982 Oct;80(2):173-80.
Radioimmunological methods have been employed for the simultaneous determination of dehydroepiandrosterone, androstenedione, testosterone, oestrogens (oestradiol + oestrone), progesterone, 17 alpha-hydroxyprogesterone and cortisol in human adipose tissue and peripheral blood to compare the hormone pool of adipose tissue with that in the general circulation. Extremely high steroid concentrations in the adipose tissue and hormone pool in the fat of obese subjects were observed. For adipose tissue/serum steroid ratios, the highest values were obtained for dehydroepiandrosterone and the lowest ones for cortisol. A preliminary study showed a great accumulation of steroids in adjacent adipose tissue of breast tumors. Striking differences were observed in the adipose tissue steroid concentrations between benign and malignant mammary tumors. The present findings revealed that blood hormone determinations may be insufficient to consider the steroid hormone availability in various endocrinopathies or steroid responsive tumors, especially when the endocrine state of extremely obese subjects is observed.
放射免疫法已用于同时测定人体脂肪组织和外周血中的脱氢表雄酮、雄烯二酮、睾酮、雌激素（雌二醇+雌酮）、孕酮、17α-羟孕酮和皮质醇，以比较脂肪组织与全身循环中的激素库。观察到肥胖受试者脂肪中的脂肪组织和激素库中类固醇浓度极高。对于脂肪组织/血清类固醇比率，脱氢表雄酮的值最高，皮质醇的值最低。一项初步研究表明，乳腺肿瘤相邻脂肪组织中类固醇大量蓄积。在良性和恶性乳腺肿瘤的脂肪组织类固醇浓度方面观察到显著差异。目前的研究结果表明，血液激素测定可能不足以考量各种内分泌疾病或类固醇反应性肿瘤中的类固醇激素可利用性，尤其是在观察极度肥胖受试者的内分泌状态时。
