Schindler A E, Aymar M
Endocrinol Exp. 1975 Sep;9(3):215-22.
The metabolism of dehydroepiandrosterone in female adipose tissue and venous blood in 11 patients was studied by a double isotope method which is described in detail. The main metabolite isolated, identified and quantitated was androstenediol. The conversion rate of dehydroepiandrosterone to androstenediol for adipose tissue ranged between 3.32-14.28% (X = 7.47 +/- 3.34 SD) and for venous blood between 2.88-9.60% (X = 5.84 +/- 1.80 SD). The values found for androstenedione and testostrone did not differ from the control experiments. Oestrone and oestradiol could not be detected. The contribution of the peripheral steroid metabolism to the pool of androgenic steroids is discussed.
采用详细描述的双同位素方法，对11例患者女性脂肪组织和静脉血中脱氢表雄酮的代谢情况进行了研究。分离、鉴定并定量的主要代谢产物为雄烯二醇。脂肪组织中脱氢表雄酮向雄烯二醇的转化率在3.32 - 14.28%之间（X = 7.47 ± 3.34标准差），静脉血中的转化率在2.88 - 9.60%之间（X = 5.84 ± 1.80标准差）。所测得的雄烯二酮和睾酮的值与对照实验无差异。未检测到雌酮和雌二醇。讨论了外周类固醇代谢对雄激素类固醇库的贡献。
