Nakashima H, Ochi H, Yasui N, Hamada H, Ono K
Eur J Nucl Med. 1982;7(12):531-5. doi: 10.1007/BF00571644.
The localization of 99mTc-methylene diphosphonate (99mTc-MDP) in mouse osteosarcoma was studied using a skeletal scintigraphic method and macro- and microautoradiographic methods. On the skeletal scintigraph, the tumor showed a high uptake of 99mTc-MDP and its concentration was about 20 times as high as the value seen in the muscular tissue. The macroautoradiography showed high activity in the tumor bone region and little activity in the nonossified region. On the microautoradiography, the activity of 99mTc-MDP was localized in the mineralized matrix of tumor bone and was almost nil in the nonmineralized matrix (osteoid) and the tumor cells. These findings indicate that the mineralization of the tumor bone matrix plays an important role in 99mTc-MDP uptake in osteosarcoma.
采用骨骼闪烁照相法以及宏观和微观放射自显影法，研究了99m锝-亚甲基二膦酸盐（99mTc-MDP）在小鼠骨肉瘤中的定位。在骨骼闪烁图上，肿瘤显示出对99mTc-MDP的高摄取，其浓度约为肌肉组织中所见值的20倍。宏观放射自显影显示肿瘤骨区域活性高，非骨化区域活性低。在微观放射自显影中，99mTc-MDP的活性定位于肿瘤骨的矿化基质中，在非矿化基质（类骨质）和肿瘤细胞中几乎为零。这些发现表明，肿瘤骨基质的矿化在骨肉瘤摄取99mTc-MDP中起重要作用。
