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双膦酸盐在体外可抑制羟基磷灰石溶解，在组织培养和体内可抑制骨吸收。

Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo.

作者信息

Fleisch H, Russell R G, Francis M D

出版信息

Science. 1969 Sep 19;165(3899):1262-4. doi: 10.1126/science.165.3899.1262.

DOI:10.1126/science.165.3899.1262
PMID:5803538
Abstract

Two diphosphonates containing the P-C-P bond, Cl(2)C(PO(3)HNa)(2), and H(2)C(PO(3)HNa)(2) retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized rats in vivo.

摘要

两种含有P-C-P键的双膦酸盐，即Cl₂C(PO₃HNa)₂和H₂C(PO₃HNa)₂，在体外可延缓磷灰石晶体的溶解速率。它们在组织培养中可抑制甲状旁腺提取物诱导的小鼠颅骨骨吸收，在体内可抑制甲状旁腺切除大鼠的骨吸收。

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Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo.双膦酸盐在体外可抑制羟基磷灰石溶解，在组织培养和体内可抑制骨吸收。
Science. 1969 Sep 19;165(3899):1262-4. doi: 10.1126/science.165.3899.1262.
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