Hoefnagel C A, Bruning P F, Cohen P, Marcuse H R, van der Schoot J B
Diagn Imaging. 1981;50(5):277-84.
The results of 99mTc-methylene diphosphonate 99mTc-MDP scintigraphy in 37 osteosarcoma patients were evaluated. In 11 of 12 patients with pulmonary metastases these were demonstrated by the scintigram. In 2 of these 11 patients the lung metastases could be shown earlier by scintigraphy than by X-ray tomography. Uptake of 99mTc-MDP appeared to be correlated with the formation of osteoid by the tumor. 99mTc-MDP scintigraphy demonstrated metastases not only in the lungs and the skeleton, but also in the lymph nodes and soft tissues. 99mTc-MDP whole-body scintigraphy should be used routinely for the early detection of osteosarcoma metastases.
对37例骨肉瘤患者的99m锝-亚甲基二膦酸盐（99mTc-MDP）闪烁扫描结果进行了评估。12例有肺转移的患者中，11例的肺转移在闪烁扫描图上得以显示。在这11例患者中的2例，闪烁扫描比X线断层扫描更早显示出肺转移。99mTc-MDP的摄取似乎与肿瘤类骨质的形成相关。99mTc-MDP闪烁扫描不仅显示了肺和骨骼的转移，还显示了淋巴结和软组织的转移。99mTc-MDP全身闪烁扫描应常规用于骨肉瘤转移的早期检测。
