Baeteman M A, Baret A, Courtière A, Rebuffel P, Mattei J F
Life Sci. 1983 Feb 21;32(8):895-902. doi: 10.1016/0024-3205(83)90227-8.
Copper and manganese superoxide dismutases (Cu-SOD and Mn-SOD) were measured by radioimmunoassay in B and T lymphocytes and macrophages, in patients with trisomy 21 and in matched controls. In the controls, Cu-SOD was present in greater amounts than Mn-SOD and there were quantitative differences in the distribution in the three cellular sub-populations. In trisomy 21, levels of Cu-SOD were raised, with no change in levels of Mn-SOD, supporting the theory of a gene dosage effect. There were significant positive and negative correlations between age and Cu-SOD levels in controls, and a correlation approaching significance for Mn-SOD. In trisomy 21, there was no correlation between age and Cu-SOD levels, and the only significant correlation for Mn-SOD was for B lymphocytes.
采用放射免疫分析法测定了21三体综合征患者及其匹配对照者的B淋巴细胞、T淋巴细胞和巨噬细胞中的铜超氧化物歧化酶（Cu-SOD）和锰超氧化物歧化酶（Mn-SOD）。在对照组中，Cu-SOD的含量高于Mn-SOD，且在三种细胞亚群中的分布存在定量差异。在21三体综合征患者中，Cu-SOD水平升高，而Mn-SOD水平无变化，这支持了基因剂量效应理论。对照组中年龄与Cu-SOD水平之间存在显著的正相关和负相关，而Mn-SOD的相关性接近显著水平。在21三体综合征患者中，年龄与Cu-SOD水平之间无相关性，Mn-SOD唯一显著的相关性存在于B淋巴细胞中。
