根据年龄，正常人和21三体综合征患者淋巴细胞亚群中的免疫反应性铜超氧化物歧化酶和锰超氧化物歧化酶

Immunoreactive Cu-SOD and Mn-SOD in lymphocytes sub-populations from normal and trisomy 21 subjects according to age.

作者信息

Baeteman M A, Baret A, Courtière A, Rebuffel P, Mattei J F

出版信息

Life Sci. 1983 Feb 21;32(8):895-902. doi: 10.1016/0024-3205(83)90227-8.

PMID:6219263

Abstract

Copper and manganese superoxide dismutases (Cu-SOD and Mn-SOD) were measured by radioimmunoassay in B and T lymphocytes and macrophages, in patients with trisomy 21 and in matched controls. In the controls, Cu-SOD was present in greater amounts than Mn-SOD and there were quantitative differences in the distribution in the three cellular sub-populations. In trisomy 21, levels of Cu-SOD were raised, with no change in levels of Mn-SOD, supporting the theory of a gene dosage effect. There were significant positive and negative correlations between age and Cu-SOD levels in controls, and a correlation approaching significance for Mn-SOD. In trisomy 21, there was no correlation between age and Cu-SOD levels, and the only significant correlation for Mn-SOD was for B lymphocytes.

摘要

采用放射免疫分析法测定了21三体综合征患者及其匹配对照者的B淋巴细胞、T淋巴细胞和巨噬细胞中的铜超氧化物歧化酶（Cu-SOD）和锰超氧化物歧化酶（Mn-SOD）。在对照组中，Cu-SOD的含量高于Mn-SOD，且在三种细胞亚群中的分布存在定量差异。在21三体综合征患者中，Cu-SOD水平升高，而Mn-SOD水平无变化，这支持了基因剂量效应理论。对照组中年龄与Cu-SOD水平之间存在显著的正相关和负相关，而Mn-SOD的相关性接近显著水平。在21三体综合征患者中，年龄与Cu-SOD水平之间无相关性，Mn-SOD唯一显著的相关性存在于B淋巴细胞中。