[四氯化碳中毒后大鼠肝脏中三磷酸腺苷酶活性的变化]
[Changes in adenosinetriphosphatase activity in rat liver after CC14 poisoning].
作者信息
Barrera G, Parola M, Amoroso L, Paradisi L, Dianzani M U
出版信息
Boll Soc Ital Biol Sper. 1982 Dec 15;58(23):1582-8.
PMID:6219684
Abstract
Our study shows evidences that CCl4 administration (at the dose of 2,5 ml/kg b.w. "per os") increased ATPase activities in rat liver plasmamembranes 1 and 2 hours after treatment. Conversely we found that CCl4 poisoning decreased ATPase activities in microsomal membranes of rat liver at the same tested times. Therefore we suggest that ATPase activities were differently influenced by CCl4 treatment with respect to different subcellular distribution of those enzymes.
摘要
我们的研究表明，给予四氯化碳（剂量为2.5毫升/千克体重，经口给药）后1至2小时，大鼠肝细胞膜中的ATP酶活性增加。相反，我们发现在相同的测试时间，四氯化碳中毒会降低大鼠肝微粒体膜中的ATP酶活性。因此，我们认为四氯化碳处理对ATP酶活性的影响因这些酶在不同亚细胞分布中的差异而有所不同。
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