McClure J
J Pathol. 1983 Apr;139(4):419-30. doi: 10.1002/path.1711390403.
Midpoint tenotomy of the mouse Achilles tendon is followed by regeneration with heterotopic ossification at the junction of tendon stump and the regenerated segment. This heterotopic bone formation occurs through a process of endochondral ossification and the cartilage cells appear to arise by a process of fibroblast transformation. Five weeks after tenotomy 60 per cent. of specimens show cartilage and bone formation whilst the remaining 40 per cent. show chondrification only. After 10 weeks all specimens showed bone formation with trabecular bone and haemopoietic marrow. The treatment of tenotomised animals with either disodium ethane-1, 1-diphosphonate (EHDP) or disodium dichloromethylene diphosphonate (Cl2MDP) has no effect on the process of heterotopic ossification which can be detected at the radiological or light microscopical level.
小鼠跟腱中点切断术后，在肌腱残端与再生段的交界处会发生再生并伴有异位骨化。这种异位骨形成是通过软骨内成骨过程发生的，软骨细胞似乎是由成纤维细胞转化过程产生的。切断术后5周，60%的标本显示有软骨和骨形成，而其余40%仅显示软骨化。10周后，所有标本均显示有小梁骨和造血骨髓的骨形成。用乙烷-1,1-二膦酸二钠（EHDP）或二氯亚甲基二膦酸二钠（Cl2MDP）治疗切断跟腱的动物，对在放射学或光学显微镜水平可检测到的异位骨化过程没有影响。
