Miyano T, Suruga K, Arai T, Nittono H, Kato H
J Pediatr Surg. 1983 Feb;18(1):42-6. doi: 10.1016/s0022-3468(83)80271-1.
Antibiotic excretion into the bile was studied using LMOX and CMZ in 16 postoperative cases of biliary atresia patients who had had hepatic portoenterostomy with Suruga II type enterostomy with the following results: Group I: Excellent excretion which was almost the same as that seen with adult patients; Group IIa: Good or poor excretion, depending on the amount of bile flow and liver function; Group IIb: Very poor excretion; Group III: Good excretion but depending on the amount of bile flow and liver function. As the total bile acid level in bile showed a higher level, the biliary excretion of antibiotics was greater. Our study indicates that antibiotic excretion into the bile in infants is closely related to the condition of the liver function and the biliary passages.
使用LMOX和CMZ对16例接受了肝门空肠吻合术（骏河II型肠造口术）的胆道闭锁术后患者进行了抗生素胆汁排泄研究，结果如下：第一组：排泄良好，几乎与成年患者相同；第二组a：排泄情况取决于胆汁流量和肝功能，排泄良好或较差；第二组b：排泄极差；第三组：排泄良好，但取决于胆汁流量和肝功能。随着胆汁中总胆汁酸水平升高，抗生素的胆汁排泄量增加。我们的研究表明，婴儿胆汁中抗生素的排泄与肝功能和胆道状况密切相关。
