Yura J, Tsuruga N, Hayashi S
Jpn J Antibiot. 1981 Jun;34(6):903-6.
This is studies concerning the absorption and excretion of cefmetazole in neonates and the excretion into the bile of infants with congenital biliary atresia. 1. The concentration of cefmetazole was measured in the serum and urine of 2 neonates at the postoperative period. 2. The concentration measured in the serum showed a level similar to those of cases in pediatrics at other institutes regardless of the operation. 3. The recovery value of cefmetazole in the urine of the neonate is not different from those of other institutes even if it is a postoperative case, provided that the urine quantity is maintained. 4. Excretion of cefmetazole into the urine and bile was measured in 2 cases of congenital biliary atresia after the biliary diversion. 5. The concentration of cefmetazole in the bile of infants with congenital biliary atresia is lower than those of adults. It follows that the recovery percentage in the bile is low but the converse was true in the urine recovery. This seemed to be due to liver dysfunction that are characteristic in congenital biliary atresia. However, the concentration of cefmetazole in the bile was sufficient to obtain effective therapeutic level.
这是关于头孢美唑在新生儿体内的吸收与排泄以及先天性胆道闭锁婴儿胆汁排泄情况的研究。1. 对2例新生儿术后血清和尿液中的头孢美唑浓度进行了测定。2. 血清中测得的浓度与其他机构儿科病例的浓度水平相似，与手术与否无关。3. 只要尿量维持正常，即使是术后病例，新生儿尿液中头孢美唑的回收值与其他机构的也无差异。4. 对2例先天性胆道闭锁患儿行胆道改道术后，测定了头孢美唑在尿液和胆汁中的排泄情况。5. 先天性胆道闭锁婴儿胆汁中头孢美唑的浓度低于成人。由此可见，胆汁中的回收百分比很低，但尿液回收情况则相反。这似乎是由于先天性胆道闭锁所特有的肝功能障碍所致。然而，胆汁中头孢美唑的浓度足以达到有效的治疗水平。
