具有非典型机制的无机汞毒性硫醇解毒剂。

Thiol antidote to inorganic mercury toxicity with an uncharacteristic mechanism.

作者信息

Giroux E, Lachmann P J

出版信息

Toxicol Appl Pharmacol. 1983 Feb;67(2):178-83. doi: 10.1016/0041-008x(83)90222-3.

PMID:6220489

Abstract

alpha-Mercapto-beta-(2-furyl)acrylic acid (MFA) significantly reduced the lethality of mercuric chloride to rats (2.2 mg Hg/kg, ip) when administered (25 mg/kg, po) at 1, 24, 48, and 72 hr. Daily administration of MFA (25 mg/kg, po) significantly reduced the lethality of daily injection of increasing amounts of mercuric chloride (1 mg Hg/kg X 7 days, 2 mg Hg/kg X 7 days, 4 mg Hg/kg X 14 days, ip). Mercury concentration in kidneys of MFA-treated rats was significantly higher than in vehicle-treated controls, whereas concentration in liver was (nonsignificantly) lower. Enhanced mercury deposition in kidney as a manifestation of antidotal effect is not characteristic of thiol chelators used in practice for mercury poisoning.

摘要

α-巯基-β-（2-呋喃基）丙烯酸（MFA）在1、24、48和72小时经口给予（25mg/kg）时，能显著降低氯化汞对大鼠（2.2mg汞/kg，腹腔注射）的致死率。每日给予MFA（25mg/kg，经口）能显著降低每日注射递增剂量氯化汞（1mg汞/kg×7天、2mg汞/kg×7天、4mg汞/kg×14天，腹腔注射）的致死率。MFA处理组大鼠肾脏中的汞浓度显著高于赋形剂处理的对照组，而肝脏中的浓度则（无显著差异）较低。肾脏中汞沉积增强作为解毒作用的表现并非实际用于汞中毒的硫醇螯合剂的特征。