Lipomodulin: a possible mediator of the action of glucocorticoids.

Lipomodulin, a protein with a MW of 40,000, is induced in many cells by glucocorticoids. This protein can mimic a variety of biological activities of glucocorticoids such as anti-inflammation, immunosuppression, and promotion of cellular differentiation. Since anti-lipomodulin antibody can block these effects of both glucocorticoids and lipomodulin, it is quite possible that lipomodulin is a mediator of glucocorticoids.