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脂皮质素(脂调素)的分离与特性研究

Isolation and characterization of lipocortin (lipomodulin).

作者信息

Hirata F, Notsu Y, Yamada R, Ishihara Y, Wano Y, Kunos I, Kunos G

出版信息

Agents Actions. 1986 Jan;17(3-4):263-6. doi: 10.1007/BF01982617.

DOI:10.1007/BF01982617
PMID:3962767
Abstract

Lipocortin is a phospholipase inhibitory protein whose synthesis is induced in various cells by glucocorticoids. At least three species with molecular weights of 40,000, 30,000, and 15,000 are presently known. This protein mimics the anti-inflammatory action of glucocorticoids in vitro as well as in vivo. The synthesis of the protein appears to be associated with the MHC genes.

摘要

脂皮质素是一种磷脂酶抑制蛋白,其合成由糖皮质激素在多种细胞中诱导产生。目前已知至少有三种分子量分别为40000、30000和15000的物种。这种蛋白质在体外和体内都能模拟糖皮质激素的抗炎作用。该蛋白质的合成似乎与主要组织相容性复合体(MHC)基因有关。

相似文献

1
Isolation and characterization of lipocortin (lipomodulin).脂皮质素(脂调素)的分离与特性研究
Agents Actions. 1986 Jan;17(3-4):263-6. doi: 10.1007/BF01982617.
2
Lipomodulin: a possible mediator of the action of glucocorticoids.脂调素:糖皮质激素作用的一种可能介质。
Adv Prostaglandin Thromboxane Leukot Res. 1983;11:73-8.
3
The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation.兔中性粒细胞中脂调素(一种磷脂酶抑制蛋白)的磷酸化调节
J Biol Chem. 1981 Aug 10;256(15):7730-3.
4
Lipocortin and vasocortin: two species of anti-inflammatory proteins mimicking the effects of glucocorticoids.脂皮质素和血管皮质素:两种模拟糖皮质激素作用的抗炎蛋白。
Pharmacol Res. 1992 Jan;25(1):1-12. doi: 10.1016/s1043-6618(05)80058-1.
5
Purification and characterization of a 32-kDa phospholipase A2 inhibitory protein (lipocortin) from human peripheral blood mononuclear cells.从人外周血单个核细胞中纯化及鉴定一种32 kDa磷脂酶A2抑制蛋白(脂皮质素)
FEBS Lett. 1987 Jul 13;219(1):169-75. doi: 10.1016/0014-5793(87)81211-5.
6
Role of lipomodulin, a phospholipase inhibitory protein, in immunoregulation by thymocytes.脂调素(一种磷脂酶抑制蛋白)在胸腺细胞免疫调节中的作用。
J Immunol. 1983 Apr;130(4):1930-6.
7
Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin 's'.地塞米松对大鼠炎性多形核中性粒细胞中类花生酸和血小板活化因子形成的抑制作用可能与脂皮质素有关。
Biochim Biophys Acta. 1988 Nov 25;963(2):248-57. doi: 10.1016/0005-2760(88)90288-3.
8
[Lipocortin--a Ca2+-binding protein which has anti-phospholipase A2 activity].脂皮质蛋白——一种具有抗磷脂酶A2活性的钙结合蛋白
Seikagaku. 1988 Jan;60(1):26-31.
9
A purified lipocortin shares the anti-inflammatory effect of glucocorticosteroids in vivo in mice.纯化的脂皮质素在小鼠体内具有与糖皮质激素相同的抗炎作用。
Br J Pharmacol. 1989 Aug;97(4):1051-8. doi: 10.1111/j.1476-5381.1989.tb12561.x.
10
Isolation of a human, endogenous, phospholipase A2 inhibitory, antiinflammatory protein.一种人源内源性磷脂酶A2抑制性抗炎蛋白的分离
Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:581-6.

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Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells. Evidence that protein kinase C modulates the Ca2+-dependent activation of phospholipase A2.

本文引用的文献

1
Identification of several species of phospholipase inhibitory protein(s) by radioimmunoassay for lipomodulin.通过脂调素放射免疫测定法鉴定几种磷脂酶抑制蛋白。
Biochem Biophys Res Commun. 1982 Nov 16;109(1):223-30. doi: 10.1016/0006-291x(82)91588-1.
2
H-2 histocompatibility region: influence on the murine glucocorticoid receptor and its response.H-2组织相容性区域:对小鼠糖皮质激素受体及其反应的影响
Science. 1982 May 28;216(4549):994-6. doi: 10.1126/science.7079749.
3
A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.
大鼠肾小球系膜细胞中前列腺素E2产生的钙依赖性。蛋白激酶C调节磷脂酶A2的钙依赖性激活的证据。
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Chemotactic peptide-induced arachidonic acid mobilization in human polymorphonuclear leukocytes.趋化肽诱导人多形核白细胞中花生四烯酸的动员。
Am J Pathol. 1988 Nov;133(2):347-54.
5
Ten years research on inflammation revisited.炎症十年研究再审视。
Agents Actions. 1989 Jan;26(1-2):4-8. doi: 10.1007/BF02126551.
6
Lipocortin-independent effect of dexamethasone on phospholipase activity in a thymic epithelial cell line.地塞米松对胸腺上皮细胞系中磷脂酶活性的不依赖脂皮质素的作用
Biochem J. 1989 Jul 15;261(2):395-400. doi: 10.1042/bj2610395.
7
Circadian rhythm of interleukin-1 production of monocytes and the influence of endogenous and exogenous glucocorticoids in man.人体单核细胞白细胞介素-1产生的昼夜节律以及内源性和外源性糖皮质激素的影响
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Calcium in renal cells. Modulation of calcium-dependent activation of phospholipase A2.肾细胞中的钙。钙依赖性磷脂酶A2激活的调节。
Environ Health Perspect. 1990 Mar;84:155-62. doi: 10.1289/ehp.9084155.
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Pharmacological implications for neuroreceptor imaging.
Eur J Nucl Med. 1991;18(7):482-502. doi: 10.1007/BF00181287.
糖皮质激素诱导的兔中性粒细胞中的一种磷脂酶A2抑制蛋白。
Proc Natl Acad Sci U S A. 1980 May;77(5):2533-6. doi: 10.1073/pnas.77.5.2533.
4
Primary cortisol resistance: a family study.原发性皮质醇抵抗:一项家族研究。
J Clin Endocrinol Metab. 1983 Jun;56(6):1243-5. doi: 10.1210/jcem-56-6-1243.
5
Glucocorticoid inhibition of zymosan-induced arachidonic acid release by rat alveolar macrophages.糖皮质激素对大鼠肺泡巨噬细胞中酵母聚糖诱导的花生四烯酸释放的抑制作用。
Am Rev Respir Dis. 1984 Nov;130(5):803-9. doi: 10.1164/arrd.1984.130.5.803.
6
Modulation of the biologic activities of IgE binding factor. VI. The activation of phospholipase by glycosylation enhancing factor.IgE结合因子生物活性的调节。VI. 糖基化增强因子对磷脂酶的激活作用。
J Immunol. 1984 Sep;133(3):1505-12.
7
Relationship between the anti-phospholipase and anti-inflammatory effects of glucocorticoid-induced proteins.糖皮质激素诱导蛋白的抗磷脂酶作用与抗炎作用之间的关系。
Eur J Pharmacol. 1984 Mar 23;99(2-3):233-9. doi: 10.1016/0014-2999(84)90246-2.
8
Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo.纯化的糖皮质激素受体在体外能选择性地与一个克隆的DNA片段结合,该片段的转录在体内受糖皮质激素调控。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6628-32. doi: 10.1073/pnas.78.11.6628.
9
The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation.兔中性粒细胞中脂调素(一种磷脂酶抑制蛋白)的磷酸化调节
J Biol Chem. 1981 Aug 10;256(15):7730-3.
10
Inhibition of human natural killer (NK) activity and antibody dependent cellular cytotoxicity (ADCC) by lipomodulin, a phospholipase inhibitory protein.
J Immunol. 1983 Aug;131(2):662-5.