万古霉素及其与乙酰-D-丙氨酰-D-丙氨酸复合物的结构。
Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine.
作者信息
Sheldrick G M, Jones P G, Kennard O, Williams D H, Smith G A
出版信息
Nature. 1978 Jan 19;271(5642):223-5. doi: 10.1038/271223a0.
DOI:10.1038/271223a0
PMID:622161
Abstract
Vancomycin, a broad-spectrum antibiotic, inhibits the growth of cell walls by complex formation with peptides terminating in D-alanyl-D-alanine. The structure of vancomycin was determined by X-ray analysis of the degradation product CDP-I. A model of the complex is proposed based on this study and spectroscopic data.
摘要
万古霉素是一种广谱抗生素，它通过与以D-丙氨酰-D-丙氨酸结尾的肽形成复合物来抑制细胞壁的生长。万古霉素的结构是通过对降解产物CDP-I进行X射线分析确定的。基于这项研究和光谱数据提出了该复合物的模型。
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