葡萄膜炎中的T淋巴细胞亚群。

T lymphocyte subsets in uveitis.

作者信息

Nussenblatt R B, Salinas-Carmona M, Leake W, Scher I

出版信息

Am J Ophthalmol. 1983 May;95(5):614-21. doi: 10.1016/0002-9394(83)90379-3.

Abstract

We evaluated the peripheral T-cell subsets in 32 adult patients with intraocular inflammatory disease and 12 age-matched normal controls by means of the OKT series of monoclonal antibodies in conjunction with the laser cytofluorograph, which quantitatively determines the fluorescence intensity of lymphocytes. We found no statistically significant difference in the ratio of OKT 4-positive (inducer) cells to OKT8-positive (suppressor) cells. However, this ratio was significantly decreased in patients with active posterior uveitis compared with controls (P less than .05). The number of OKT8-positive T lymphocytes in this group was significantly increased (P less than .01), causing a decrease in the OKT4-OKT8 ratio. In patients with positive in vitro cell-mediated responses to the retinal S-antigen, a statistically significant (P less than .05) decrease was found as well only in the patients with active disease.

摘要

我们通过OKT系列单克隆抗体结合激光细胞荧光光度计对32例成年眼内炎性疾病患者和12例年龄匹配的正常对照者的外周血T细胞亚群进行了评估，该仪器可定量测定淋巴细胞的荧光强度。我们发现OKT 4阳性（诱导）细胞与OKT8阳性（抑制）细胞的比例无统计学显著差异。然而，与对照组相比，活动性后葡萄膜炎患者的这一比例显著降低（P<0.05）。该组中OKT8阳性T淋巴细胞数量显著增加（P<0.01），导致OKT4-OKT8比例降低。在对视网膜S抗原体外细胞介导反应呈阳性的患者中，仅在活动性疾病患者中也发现有统计学显著（P<0.05）降低。