Deslypere J P, de Biscop G, Vermeulen A
Clin Endocrinol (Oxf). 1983 Jan;18(1):25-30. doi: 10.1111/j.1365-2265.1983.tb03182.x.
Urinary levels of the glucuronides of androsterone, aetiocholanolone, 5 alpha-androstane-3 alpha, 17 beta-diol and 5 beta-androstane-3 alpha, 17 beta-diol, were determined in twenty-two-post menopausal women both in spring and in autumn--winter. In sixteen women dehydroepiandrosterone sulphate plasma levels were also measured. Plasma DHAS levels as well as urinary metabolite excretion values were significantly higher in autumn--winter than in spring. This seasonal variability should be taken into account in long-term studies involving adrenal hormone levels, excretion or metabolism. Moreover this seasonal variability might be of relevance for the cyclical growth rate of hormone dependent tumours such as breast cancer.
测定了22名绝经后女性在春季以及秋冬季节尿中雄甾酮、本胆烷醇酮、5α-雄烷-3α,17β-二醇和5β-雄烷-3α,17β-二醇葡糖醛酸苷的水平。还测定了16名女性血浆硫酸脱氢表雄酮的水平。秋冬季节的血浆硫酸脱氢表雄酮水平以及尿代谢产物排泄值显著高于春季。在涉及肾上腺激素水平、排泄或代谢的长期研究中应考虑这种季节性变化。此外，这种季节性变化可能与激素依赖性肿瘤如乳腺癌的周期性生长速率有关。
