Barroeta O, Nungaray L, López-Osuna M, Armendares S, Salamanca F, Kretschmer R R
Pediatr Res. 1983 Apr;17(4):292-5. doi: 10.1203/00006450-198304000-00013.
Under-agarose random migration, chemokinesis and chemotaxis of monocytes from 36 patients with Down's syndrome were compared to those of monocytes from 42 healthy, age-matched control children. Random migration of monocytes from patients with Down's syndrome was comparable to that of controls. In contrast, chemotaxis of monocytes from patients with Down's syndrome was significantly decreased (P less than 0.001) when compared to that of controls, even though chemokinesis was significantly increased (P less than 0.001). Age, sex, and physical development of patients with Down's syndrome or of control children included in this study had no apparent effect upon monocyte mobility.
将36例唐氏综合征患者的单核细胞在琼脂糖下的随机迁移、化学运动性和趋化性与42例年龄匹配的健康对照儿童的单核细胞进行了比较。唐氏综合征患者单核细胞的随机迁移与对照组相当。相比之下，唐氏综合征患者单核细胞的趋化性与对照组相比显著降低（P<0.001），尽管化学运动性显著增加（P<0.001）。本研究中纳入的唐氏综合征患者或对照儿童的年龄、性别和身体发育对单核细胞迁移率无明显影响。
