Achey P M, Wright C F
Radiat Res. 1983 Mar;93(3):609-12.
The susceptibility to inducible SOS repair of 5,6-dihydroxy-dihydrothymine (t') damage in single-stranded phi X174 DNA has been measured. Following exposure to osmium tetroxide, which introduces t' damage in DNA under the conditions used, biological survival of the DNA infected into spheroplasts of Escherichia coli which had received prior exposure to ultraviolet light was higher than in unexposed spheroplasts. From our results, we conclude that approximately 63% of the biological damage from t' products, which is one of the classes of damage present in DNA following ionizing radiation, is susceptible to repair by the inducible SOS repair system.
已测定了单链φX174 DNA中5,6-二羟基-二氢胸腺嘧啶（t'）损伤的可诱导SOS修复敏感性。在使用的条件下，四氧化锇会在DNA中引入t'损伤，将暴露于四氧化锇后的DNA感染到先前已暴露于紫外线的大肠杆菌原生质球中，其生物学存活率高于未暴露的原生质球。根据我们的结果，我们得出结论，t'产物造成的约63%的生物学损伤（t'产物是电离辐射后DNA中存在的一类损伤）可被可诱导的SOS修复系统修复。
