Lafleur M V, Woldhuis J, Loman H
Int J Radiat Biol Relat Stud Phys Chem Med. 1980 May;37(5):493-8. doi: 10.1080/09553008014550611.
The effect of sulphydryl compounds on the induction of alkali-labile sites and on the contribution of such sites to the inactivation of single-stranded phi X174 DNA was studied. Cysteamine is capable of reacting with DNA radicals, thereby modifying the radiation damage in such a way that the induction of immediate and latent breaks is reduced. This depends on the pH of the solution. With cysteine only, a pH dependent protection, against lethal alkali-labile potential breaks could be observed. The damage other than breaks is not influenced by the presence of sulphydryl compounds.
研究了巯基化合物对碱不稳定位点诱导的影响以及此类位点对单链φX174 DNA失活的贡献。半胱胺能够与DNA自由基反应，从而以减少即时和潜在断裂诱导的方式改变辐射损伤。这取决于溶液的pH值。仅使用半胱氨酸时，可以观察到对致死性碱不稳定潜在断裂的pH依赖性保护作用。除断裂之外的损伤不受巯基化合物存在的影响。
