Steinman T I, Silva P
Am J Med. 1983 Jul;75(1):154-6. doi: 10.1016/0002-9343(83)91180-4.
A case of acute renal failure associated with captopril administration is reported. A woman, age 57, with a two-year history of hypertension presented with a generalized maculopapular rash preceded by pruritus after three weeks of captopril therapy. Her serum creatinine level on admission was 11.0 mg/dl. Renal biopsy was compatible with acute tubular necrosis without evidence of interstitial nephritis. A skin biopsy did not show any evidence of vasculitis. Captopril was discontinued, and her renal failure reversed over the course of nine days. A year later, the patient has good blood pressure control with stable renal function. Captopril has been associated with renal failure in patients with preexisting renovascular hypertension, and with acute interstitial nephritis in one case. The presentation of this case was similar to the latter case, but the renal biopsy did not show any evidence of acute interstitial nephritis.
报告了1例与服用卡托普利相关的急性肾衰竭病例。一名57岁女性，有2年高血压病史，在接受卡托普利治疗3周后，出现瘙痒，随后出现全身性斑丘疹。入院时她的血清肌酐水平为11.0mg/dl。肾活检符合急性肾小管坏死，无间质性肾炎证据。皮肤活检未显示血管炎证据。停用卡托普利后，她的肾衰竭在9天内逆转。1年后，患者血压控制良好，肾功能稳定。卡托普利已被证明与已有肾血管性高血压患者的肾衰竭相关，且有1例与急性间质性肾炎相关。本病例的表现与后一种情况相似，但肾活检未显示急性间质性肾炎证据。
