Cox F E
Parasitology. 1978 Feb;76(1):55-60. doi: 10.1017/s0031182000047387.
Mice which have recovered from infections with the avirulent piroplasm Babesia microti are also resistant to challenge with the virulent malaria parasite Plasmodium vinckei. In mice infected with P. vinckei before the peak of the B. microti infection the numbers of malaria parasites in the blood increase until that peak and are then eliminated at the same time as the piroplasms. In mice infected with P. vinckei at or after the peak there is no apparent multiplication and the malaria parasites begin to disappear from the blood immediately. The malaria parasites in doubly infected mice show signs of degeneration similar to those seen in mice pre-treated with Corynebacterium parvum and it is suggested that a common mechanism exists in homologous and heterologous immunity and in immunity following pre-treatment with C. parvum or BCG.
从无毒梨浆虫微小巴贝斯虫感染中恢复的小鼠，对有毒疟原虫文氏疟原虫的攻击也具有抗性。在微小巴贝斯虫感染高峰期之前感染文氏疟原虫的小鼠，血液中的疟原虫数量会增加直至达到该峰值，然后与梨浆虫同时被清除。在高峰期或之后感染文氏疟原虫的小鼠中，疟原虫没有明显增殖，且疟原虫立即开始从血液中消失。双重感染小鼠体内的疟原虫表现出与用短小棒状杆菌预处理的小鼠相似的退化迹象，这表明同源免疫和异源免疫以及用短小棒状杆菌或卡介苗预处理后的免疫存在共同机制。
