Wood P R, Clark I A
Parasite Immunol. 1982 Sep;4(5):319-27. doi: 10.1111/j.1365-3024.1982.tb00443.x.
Increased natural killer (NK) cell activity was found in the spleen and peritoneal cavity of mice infected with Babesia microti or Plasmodium vinckei petteri. This increased activity appeared not to be associated with the effectiveness of the host response against these parasites, since it reached its maximum when the parasitaemia was still low, and had decreased by the time the parasites reached peak densities. In addition mice pretreated with 89Strontium of 17 beta-oestradiol experienced the same pattern of infection as did control mice, yet the infections induced much lower levels of NK activity in the pretreated mice. The course of infection with B. microti was also unaltered in beige mice, which are genetically deficient in NK cells. Thus we consider it unlikely that NK cells are of primary importance in non-specific immunity to these haemoprotozoan infections.
在感染微小巴贝斯虫或文氏疟原虫彼得氏疟原虫的小鼠脾脏和腹腔中发现自然杀伤（NK）细胞活性增加。这种活性增加似乎与宿主针对这些寄生虫的反应有效性无关，因为当寄生虫血症仍很低时它达到最大值，而当寄生虫达到峰值密度时其活性已下降。此外，用89锶或17β-雌二醇预处理的小鼠与对照小鼠经历相同的感染模式，但预处理小鼠中感染诱导的NK活性水平要低得多。在NK细胞基因缺陷的米色小鼠中，微小巴贝斯虫的感染过程也未改变。因此，我们认为NK细胞在对这些血原虫感染的非特异性免疫中不太可能起主要作用。
