Johnson M D, Grignolo A, Kuhn C M, Schanberg S M
Life Sci. 1983 Jul 11;33(2):169-80. doi: 10.1016/0024-3205(83)90410-1.
Chronic continuous infusion of norepinephrine (NE) or epinephrine (Epi) subcutaneously in rats resulted in rapid elevation of systolic blood pressure (SBP) by 40 mm Hg. Pressure remained high for the duration of the infusion but rapidly returned to control levels after its termination. Pronounced hypertrophy of the thoracic aorta, abdominal aorta and heart was evident within 2 days of the initiation of NE infusion and a plateau was attained by 5 days of infusion. The activity of tissue ornithine decarboxylase (ODC), the rate limiting enzyme in polyamine biosynthesis, was elevated preceeding the onset of tissue hypertrophy, and returned to control levels coincidentally with the cessation of accelerated tissue growth. It is concluded that high blood pressure in this animal model of hypertension is dependent upon the continued presence of exogenous catecholamine, and that pronounced cardiovascular hypertrophy per se is not sufficient to maintain the hypertension. The elevation and decline of vascular ODC activity is consistent with reports that in other tissues an elevation of ODC activity is an obligatory early event in hypertrophy.
在大鼠皮下慢性持续输注去甲肾上腺素（NE）或肾上腺素（Epi）会导致收缩压（SBP）迅速升高40毫米汞柱。在输注期间血压一直保持在较高水平，但在输注终止后迅速恢复到对照水平。在开始输注NE的2天内，胸主动脉、腹主动脉和心脏明显出现显著肥大，输注5天时达到平台期。组织鸟氨酸脱羧酶（ODC）是多胺生物合成中的限速酶，其活性在组织肥大开始之前升高，并在加速的组织生长停止时恢复到对照水平。得出的结论是，在这种高血压动物模型中，高血压依赖于外源性儿茶酚胺的持续存在，并且明显的心血管肥大本身不足以维持高血压。血管ODC活性的升高和下降与其他组织中ODC活性升高是肥大过程中必不可少的早期事件的报道一致。
