Carlier P G, Crine A F, Yerna N M, Rorive G L
Département de Médecine, Université de Liège, Belgium.
J Hypertens Suppl. 1988 Dec;6(4):S112-5. doi: 10.1097/00004872-198812040-00032.
The cardiovascular structural remodelling associated with psychogenic hypertension was investigated in genetically normotensive rats subjected to isolation stress. Male Wistar rats were stressed by intermittent social isolation and compared to control rats living in groups. The stressed rats had higher systolic blood pressures than the control rats throughout the study. After 1 week of isolation, ornithine decarboxylase activity, a marker for hypertrophy, was increased in the right ventricle of the stressed rats. After 6 weeks of intermittent isolation, the myocardium of the stressed rats was hypertrophied, involving both right and left ventricles. The aorta was also hypertrophied, whereas the tail artery remained unaffected. Later, after 12 weeks of isolation, the left ventricular hypertrophy persisted whereas the right ventricle and aorta returned to normal. It seems, therefore, that social stress hypertension is accompanied by very early structural changes, which affect at least the heart and the aorta, and cannot be directly linked to the severity or duration of hypertension.
在经历隔离应激的遗传性正常血压大鼠中，研究了与精神性高血压相关的心血管结构重塑。雄性Wistar大鼠通过间歇性社会隔离施加应激，并与群居的对照大鼠进行比较。在整个研究过程中，应激大鼠的收缩压高于对照大鼠。隔离1周后，应激大鼠右心室中作为肥大标志物的鸟氨酸脱羧酶活性增加。间歇性隔离6周后，应激大鼠的心肌肥大，累及右心室和左心室。主动脉也肥大，而尾动脉未受影响。后来，隔离12周后，左心室肥大持续存在，而右心室和主动脉恢复正常。因此，似乎社会应激性高血压伴随着非常早期的结构变化，这些变化至少影响心脏和主动脉，并且不能直接与高血压的严重程度或持续时间相关联。
