Lehner T
Ann N Y Acad Sci. 1983 Jun 30;409:273-83. doi: 10.1111/j.1749-6632.1983.tb26876.x.
Natural sensitization of human lymphocytes to a SA, isolated from Streptococcus mutans, has been investigated by stimulating T-lymphocytes in vitro with the streptococcal antigen. Helper or suppressor activity released by the lymphocytes was then tested for anti-DNP antibody-forming cells. A differential dose-response of about 1000 ng of SA was found between the specific helper function of HLA DRw6 and DR4 lymphocytes. Specific suppressor activity showed a reciprocal relationship to helper activity. Depletion of suppressor cells, by killing these with the monoclonal T8 antiserum and complement, resulted in loss of suppressor, but increased dose response in helper function. Conversely, helper-cell-depleted cultures showed a loss of helper and increased dose response in suppressor function. The results suggest a reciprocal controlling function of helper and suppressor cells. The HLA-DR linked antigens might be related to significant shifts in the dose response of helper cells.
通过用链球菌抗原在体外刺激T淋巴细胞，对从变形链球菌中分离出的一种表面抗原（SA）引起的人淋巴细胞自然致敏作用进行了研究。然后检测淋巴细胞释放的辅助或抑制活性对抗二硝基苯酚（DNP）抗体形成细胞的影响。在HLA DRw6和DR4淋巴细胞的特异性辅助功能之间发现了约1000 ng SA的差异剂量反应。特异性抑制活性与辅助活性呈反比关系。用单克隆T8抗血清和补体杀死抑制细胞，导致抑制作用丧失，但辅助功能的剂量反应增加。相反，辅助细胞耗尽的培养物显示辅助功能丧失，而抑制功能的剂量反应增加。结果表明辅助细胞和抑制细胞具有相互控制功能。与HLA-DR相关的抗原可能与辅助细胞剂量反应的显著变化有关。
