Fujimoto S, Orita K, Kimura T, Kondo T, Taguchi T, Yoshida K, Ogawa N, Furue H
Gan To Kagaku Ryoho. 1983 Apr;10(4 Pt 2):1135-45.
SPG, a beta-1, 3 glucan extracted from cultured Schizophyllum commune Fries, was clinically evaluated for its efficacy in adjuvant immunochemotherapy for postoperative gastric cancer by the SPG cooperative study group comprising 43 hospitals. On the day of operation and the next day, patients were given intravenously 0.4 mg and 0.2 mg/kg of mitomycin C, respectively. Subsequently, they were randomly allocated to either the SPG group or control group. From the 10th to 20th postoperative days, the SPG group was intramuscularly given SPG at a dose of 20 mg twice a week or 40 mg once a week in combination with tegafur, while the control group was given only tegafur. Significant prolongation of life span of the SPG group was confirmed in Stage III. Minor side effects due to SPG were noted in 2.6% (5/190).
裂褶多糖（SPG）是从培养的裂褶菌（Schizophyllum commune Fries）中提取的一种β-1,3-葡聚糖，由43家医院组成的SPG合作研究组对其在胃癌术后辅助免疫化疗中的疗效进行了临床评估。在手术当天和次日，患者分别静脉注射0.4毫克和0.2毫克/千克的丝裂霉素C。随后，他们被随机分配到SPG组或对照组。术后第10天至20天，SPG组每周两次肌肉注射20毫克SPG或每周一次肌肉注射40毫克SPG，并联合替加氟，而对照组仅给予替加氟。在III期患者中证实SPG组的生存期显著延长。2.6%（5/190）的患者出现了与SPG相关的轻微副作用。
