Mitani M, Iwano K, Arika T, Kikuchi M
Gan To Kagaku Ryoho. 1982 Jan;9(1):122-8.
Immunochemotherapy with schizophyllan (SPG) combined with chemotherapeutic agents was evaluated in two syngeneic tumor-C3H/He mouse systems. The administration of SPG alone caused a significant growth inhibition of MM 46 mammary carcinoma, the highest therapeutic effect being obtained by SPG given at the advanced stage of tumors. When combined with neocarzinostatin given 7-times every other day the simultaneous administration of SPG produced an optimal response to that therapy. In X-5563 plasmacytoma, SPG alone was ineffective. However, when combined with mitomycin C given with 1 to 5-days interval, the concurrent administration of SPG prolonged significantly the life-span of the tumor-bearing mice. These results indicated that the simultaneous administration of SPG and antitumor drugs may be a useful application method for immunochemotherapy of experimental tumors.
在两种同基因肿瘤 - C3H/He小鼠模型系统中评估了裂褶多糖（SPG）与化疗药物联合的免疫化疗效果。单独给予SPG可显著抑制MM 46乳腺癌的生长，在肿瘤晚期给予SPG可获得最高治疗效果。当与每隔一天给药7次的新制癌菌素联合使用时，同时给予SPG可产生对该疗法的最佳反应。在X - 5563浆细胞瘤中，单独使用SPG无效。然而，当与间隔1至5天给药的丝裂霉素C联合使用时，同时给予SPG可显著延长荷瘤小鼠的寿命。这些结果表明，同时给予SPG和抗肿瘤药物可能是实验性肿瘤免疫化疗的一种有用应用方法。
