Semenzato G, Pezzutto A, Foa R, Lauria F, Raimondi R
Clin Immunol Immunopathol. 1983 Feb;26(2):155-61. doi: 10.1016/0090-1229(83)90133-2.
In 35 patients with B-cell chronic lymphocytic leukemia (B-CLL), T lymphocytes were characterized by their ability to react with OKT-4 and OKT-8 monoclonal antibodies. These T-cell subsets were also compared with the expression of Fc receptors. An imbalance in the distribution of OKT-4 and OKT-8 lymphocyte subpopulations was observed, with an overall significant reduction in the OKT-4/OKT-8 ratio. When the patients were subdivided according to Rai's staging classification, the OKT-4/OKT-8 ratio was more severely impaired in stages III and IV than in stages 0, I, and II. The correlation between the expression of Fc receptors and monoclonal antibodies revealed in both systems an increase in cells bearing suppressor phenotypes (OKT-8+ and TG+ cells) and a decrease in cells bearing helper phenotypes (OKT-4+ and TM+). However, a strict correlation between cells defined by the two assays could not be found in individual cases. In some cases a proportion of T lymphocytes (E+ and OKT-3+) did not express the OKT-4 and OKT-8 determinants; possible implications of this finding are discussed. These data provide further evidence of the T-cell abnormality in B-CLL and emphasize the importance of T-cell subsets in this disease.
在35例B细胞慢性淋巴细胞白血病（B-CLL）患者中，T淋巴细胞通过其与OKT-4和OKT-8单克隆抗体反应的能力进行表征。这些T细胞亚群还与Fc受体的表达进行了比较。观察到OKT-4和OKT-8淋巴细胞亚群的分布失衡，OKT-4/OKT-8比值总体显著降低。当根据Rai分期分类对患者进行细分时，III期和IV期的OKT-4/OKT-8比值受损比0期、I期和II期更严重。Fc受体表达与单克隆抗体之间的相关性在两个系统中均显示出具有抑制表型的细胞（OKT-8+和TG+细胞）增加，而具有辅助表型的细胞（OKT-4+和TM+细胞）减少。然而，在个别病例中未发现两种检测方法所定义的细胞之间存在严格的相关性。在某些情况下，一部分T淋巴细胞（E+和OKT-3+）不表达OKT-4和OKT-8决定簇；讨论了这一发现的可能意义。这些数据为B-CLL中T细胞异常提供了进一步的证据，并强调了T细胞亚群在该疾病中的重要性。
