Brown J M, Poston S M
J Med Microbiol. 1983 Aug;16(3):271-80. doi: 10.1099/00222615-16-3-271.
Strains of propionibacteria resistant to clindamycin or clindamycin and erythromycin were isolated from four patients with acne, three of whom were receiving clindamycin. Four strains of P. acnes and one of P. granulosum with moderate levels of tetracycline resistance were isolated from 25 patients with acne being treated with tetracycline. A similar increase in tetracycline resistance was achieved by training sensitive strains in vitro. P. acnes was sensitive to sulphonamide and trimethoprim but some strains of P. granulosum were resistant to sulphonamide. Similar reports of clindamycin and erythromycin resistance from the USA suggest resistance may be increasing in isolates from patients with acne.
从4名痤疮患者中分离出对克林霉素或克林霉素及红霉素耐药的丙酸杆菌菌株，其中3名患者正在接受克林霉素治疗。从25名正在接受四环素治疗的痤疮患者中分离出4株痤疮丙酸杆菌和1株对四环素耐药水平中等的颗粒丙酸杆菌。通过在体外培养敏感菌株，也实现了四环素耐药性的类似增加。痤疮丙酸杆菌对磺胺类药物和甲氧苄啶敏感，但一些颗粒丙酸杆菌菌株对磺胺类药物耐药。来自美国的关于克林霉素和红霉素耐药性的类似报告表明，痤疮患者分离株中的耐药性可能正在增加。
