单相抑郁症中的促甲状腺激素释放激素试验与尿中3-甲氧基-4-羟基苯乙二醇

The TRH test and urinary MHPG in unipolar depression.

作者信息

Sternbach H A, Kirstein L, Pottash A L, Gold M S, Extein I, Sweeney D R

出版信息

J Affect Disord. 1983 Aug;5(3):233-7. doi: 10.1016/0165-0327(83)90046-0.

Abstract

Twenty-five men and 26 women with major unipolar depression were evaluated by the TRH test and urinary MHPG excretion. A significant positive correlation between TSH response to TRH and urinary MHPG was found in the men, though not in the women. These findings suggest that at least for depressed men, central norepinephrine deficiency may be the neurobiological substrate of blunted TSH responses to TRH.

摘要

对25名患有重度单相抑郁症的男性和26名患有重度单相抑郁症的女性进行了促甲状腺激素释放激素（TRH）测试和尿中3-甲氧基-4-羟基苯乙二醇（MHPG）排泄量评估。结果发现，男性的促甲状腺激素对TRH的反应与尿中MHPG之间存在显著正相关，而女性则不存在这种相关性。这些发现表明，至少对于抑郁男性而言，中枢去甲肾上腺素缺乏可能是促甲状腺激素对TRH反应迟钝的神经生物学基础。