Wood B P, Katzberg R W, Ryan D H, Karch F E
Radiology. 1978 Feb;126(2):441-4. doi: 10.1148/126.2.441.
Rats were given enemas of Gastrografin in two strengths, Renografin--76, and Tween--80 in a 10% dilution. There were no deleterious effects on the colons with these media used in volumes to fill the colon. Severe changes resulted from volumes which produced overdistention.