Morris T W, Sahler L G, Whynot L K, Hayakawa K
Radiology. 1984 Jul;152(1):203-4. doi: 10.1148/radiology.152.1.6729112.
Angiovist 370, a new formulation of meglumine/sodium diatrizoate, is being marketed for coronary arteriography. Angiovist 370 contains no significant calcium chelator additives, but according to manufacturer specifications may have a pH as low as 6.0. The contact times required to produce ventricular fibrillation with Angiovist 370 and with Renografin 76 were compared using a canine right coronary arteriography model. The fibrillation contact time was 32.2% longer for the Angiovist 370 than for the Renografin 76. The lower pH therefore does not appear to increase the risk of contrast media induced fibrillation. The increased contact time and safety factor with the Angiovist 370 is most likely related to the absence of calcium chelators in the formulation.
碘克沙醇370，一种新的葡甲胺/泛影葡胺制剂，正在用于冠状动脉造影的市场销售。碘克沙醇370不含显著的钙螯合剂添加剂，但根据制造商规格，其pH值可能低至6.0。使用犬右冠状动脉造影模型比较了碘克沙醇370和泛影葡胺76产生心室颤动所需的接触时间。碘克沙醇370的颤动接触时间比泛影葡胺76长32.2%。因此，较低的pH值似乎不会增加造影剂诱发颤动的风险。碘克沙醇370接触时间的增加和安全系数的提高很可能与制剂中不含钙螯合剂有关。
