Babayan R K, Osband M E, Carpinito G A, Ho Z S, Cohen E B, Krane R J
J Surg Oncol. 1983 Sep;24(1):53-8. doi: 10.1002/jso.2930240113.
A poorly differentiated transitional cell carcinoma in C3H/He mice results from the oral ingestion of the urinary tract carcinogen FANFT. This model, designated MBT2, is readily transplantable into syngeneic animals and has proven to be very useful in the development of chemotherapy. Prior to the use of this model for the testing of potential immunotherapeutic strategies, we have attempted to characterize the immunobiology of this tumor line. We report that the primary growth of this tumor in the footpad and its metastasis to lung are correlated with the development of increased numbers of suppressor cells, characterized by the expression of a surface histamine H2 receptor. These cells are originally evident in spleen and become maximal approximately 4 weeks after tumor implantation. This is followed by the migration of these cells from spleen to peripheral blood, an event that parallels the growth and eventual metastasis of this implanted transitional cell carcinoma. These events may have important significance for the development of immunomodulating therapy against bladder cancer.
C3H/He小鼠口服尿路致癌物FANFT会引发低分化移行细胞癌。这种名为MBT2的模型很容易移植到同基因动物体内，并且已被证明在化疗研发中非常有用。在将该模型用于测试潜在免疫治疗策略之前，我们试图对该肿瘤系的免疫生物学特性进行描述。我们报告称，该肿瘤在足垫的原发性生长及其向肺部的转移与抑制细胞数量增加的发展相关，这些抑制细胞以表面组胺H2受体的表达为特征。这些细胞最初在脾脏中明显可见，并在肿瘤植入后约4周达到最大值。随后这些细胞从脾脏迁移到外周血，这一事件与这种植入的移行细胞癌的生长和最终转移并行。这些事件可能对膀胱癌免疫调节治疗的发展具有重要意义。
