Mei H, Hagen I K, Allhoff E P, Lin J C, Chapman C M, Proppe K H, Prout G R, Lin C W
J Urol. 1982 Sep;128(3):629-32. doi: 10.1016/s0022-5347(17)53081-5.
A model for focal bladder carcinoma in rats was developed with the use of an isograft technique. Bladder tumors developed by carcinogen induction with FANFT or MNU were grafted to bladders of syngeneic rats. Ninety-six per cent (56 our of 58) of the grafts were taken and 83 per cent (34 out of 41) of the grafted tumors remained neoplastic. Most of the grafts from FANFT-induced tumor remained localized at the original site whereas many from the MNU-induced tumor spread beyond the original graft area. The model system may be useful for the evaluation of chemotherapeutic agents as well as for the studies of basic mechanisms of tumor growth and spreading.
采用同基因移植技术建立了大鼠局灶性膀胱癌模型。用FANFT或MNU诱导致癌物产生的膀胱肿瘤被移植到同基因大鼠的膀胱中。96%（58个中有56个）的移植物被接受，83%（41个中有34个）的移植肿瘤仍为肿瘤性。大多数来自FANFT诱导肿瘤的移植物仍局限于原部位，而许多来自MNU诱导肿瘤的移植物扩散到原移植区域之外。该模型系统可用于评估化疗药物以及研究肿瘤生长和扩散的基本机制。
