Haras D, Mahoudo H, Bourtourault M, Samperez S, Jouan P
C R Seances Soc Biol Fil. 1983;177(3):283-9.
In uteri from adult female rats, Thymidine Kinase activity varied during ovarian cycle and was maximum at metestrus. Subcutaneous injections of 5, 10 or 25 ng of estradiol-17 beta to immature female rats, resulted in a 3, 5 or 10 fold increase of enzyme activity. Moreover, Thymidine Kinase activity was decreased by injection of medroxyprogesterone alone or associated with estradiol-17 beta. From these results it seemed that Thymidine Kinase activity in rats uteri was specifically induced by estradiol-17 beta.
在成年雌性大鼠的子宫中，胸苷激酶活性在卵巢周期中有所变化，在动情后期达到最高。对未成熟雌性大鼠皮下注射5、10或25纳克的17β-雌二醇，会使酶活性增加3、5或10倍。此外，单独注射甲羟孕酮或与17β-雌二醇联合注射会降低胸苷激酶活性。从这些结果来看，似乎大鼠子宫中的胸苷激酶活性是由17β-雌二醇特异性诱导的。
