Basch R S, Buxbaum J N, Zolla-Pazner S
Cell Immunol. 1983 Oct 1;81(1):144-56. doi: 10.1016/0008-8749(83)90220-4.
The sera of mice surviving challenge with a Thy-1-negative variant of the thymoma RL male 1 contain antibodies which identify a new cell surface antigen (Ly RL male 1) present on cells of the T lineage. This antigen appears early in the development of the lineage and it can be detected on most thymocyte precursors. Its presence on prothymocytes can serve to distinguish these cells from their multipotential precursors. The antigen is present on many thymocytes, and dividing thymocytes are more susceptible to its cytotoxic activity than is the total population. Ly RL male 1-antigen-positive cells can be detected in peripheral lymphoid tissues by both functional assays and absorption. Treatment of peripheral lymphoid cells with the antiserum leads to significant reduction in MLR and helper activity but does not alter mitogen reactivity or lymphocytotoxicity. Animals with significant serum levels of anti-RL male 1 are deficient in their ability to produce IgG antibody to sheep erythrocytes.
用胸腺瘤RL雄性1的Thy-1阴性变体攻击后存活的小鼠血清中含有抗体，这些抗体可识别T谱系细胞上存在的一种新的细胞表面抗原（Ly RL雄性1）。这种抗原在该谱系发育的早期出现，并且可以在大多数胸腺细胞前体上检测到。其在原胸腺细胞上的存在可用于将这些细胞与其多能前体区分开来。该抗原存在于许多胸腺细胞上，并且正在分裂的胸腺细胞比整个群体更容易受到其细胞毒性活性的影响。通过功能测定和吸附法均可在外周淋巴组织中检测到Ly RL雄性1抗原阳性细胞。用抗血清处理外周淋巴细胞会导致混合淋巴细胞反应（MLR）和辅助活性显著降低，但不会改变有丝分裂原反应性或淋巴细胞毒性。血清中抗RL雄性1水平较高的动物产生针对绵羊红细胞的IgG抗体的能力不足。
