Daw N W, Berman N E, Ariel M
Science. 1978 Feb 3;199(4328):565-7. doi: 10.1126/science.622560.
The critical period for modifying the preferred direction in cat cortical units occurs earlier than that for monocular deprivation. The independence of the effects of these two types of deprivation from each other was tested by rearing six kittens with both reverse suture and reversed directional deprivation. The kittens were placed in a drum rotating in one direction with one eye open at ages 2 1/2 to 5 weeks; the drum rotation was reversed and the other eye opened when they were 5 to 12 weeks old. Recordings were then made in the visual cortex. The results were the sum of the effects of reverse suture and reversal of directional deprivation: most cells were driven by the eye that was open second, and most unidirectional cells preferred the direction to which the animals were exposed first. Consequently, many unidirectional cells preferred the first direction but were driven by the eye open second--a combination that the animal never saw during rearing. There was also an effect of ocular deprivation on directional properties and vice versa: reverse suture reduced the overall percentage of unidirectional cells, just as directional deprivation has been shown to affect the ocular dominance histogram. This result suggests that the same cells may be affected by both forms of deprivation.
猫皮层神经元中偏好方向改变的关键期比单眼剥夺的关键期出现得更早。通过饲养6只经历反向缝合和反向方向剥夺的小猫，测试了这两种剥夺效应之间的独立性。在2.5至5周龄时，将小猫置于一个朝一个方向旋转的鼓中，睁开一只眼睛；当它们5至12周龄时，鼓的旋转方向反转，另一只眼睛睁开。然后在视觉皮层进行记录。结果是反向缝合和方向剥夺反转效应的总和：大多数细胞由后睁开的眼睛驱动，大多数单向细胞偏好动物首先接触的方向。因此，许多单向细胞偏好第一个方向，但由后睁开的眼睛驱动——这是动物在饲养过程中从未见过的组合。眼剥夺对方向特性也有影响，反之亦然：反向缝合降低了单向细胞的总体百分比，就像方向剥夺已被证明会影响眼优势直方图一样。这一结果表明，相同的细胞可能受到两种剥夺形式的影响。
