Ponte C D
Drug Intell Clin Pharm. 1983 Sep;17(9):642-4. doi: 10.1177/106002808301700908.
Carbamazepine is an anticonvulsant agent that has been found clinically useful in the treatment of refractory seizure disorders. Its mechanism of action is not well understood. The drug also has been associated with several serious side-effects. These include bone marrow suppression, liver and renal dysfunction, water intoxication, and ocular lens opacities. A 33-year-old white female developed elevated liver enzymes, a rash, and thrombocytopenia following the short-term use of carbamazepine for temporal lobe seizures. All of these findings are consistent with literature reports. Other etiologic factors also are discussed. This case is presented to illustrate the importance of monitoring blood counts and liver function tests when carbamazepine is part of a particular treatment regimen. Clinicians must be aware that a variety of hematological disorders can occur with this drug. Liver dysfunction is usually first noted, with an elevation of liver function tests. When thrombocytopenia is noted, prompt withdrawal of the drug is required. The platelet count should return to normal within a few days.
卡马西平是一种抗惊厥药，临床已发现其对治疗难治性癫痫疾病有用。其作用机制尚不完全清楚。该药物还与多种严重副作用相关。这些副作用包括骨髓抑制、肝肾功能障碍、水中毒和晶状体混浊。一名33岁白人女性在短期使用卡马西平治疗颞叶癫痫后出现肝酶升高、皮疹和血小板减少。所有这些发现与文献报道一致。还讨论了其他病因。介绍该病例是为了说明当卡马西平作为特定治疗方案的一部分时，监测血细胞计数和肝功能测试的重要性。临床医生必须意识到使用该药物可能会出现多种血液系统疾病。通常首先会注意到肝功能障碍，表现为肝功能测试升高。当发现血小板减少时，需要立即停药。血小板计数应在几天内恢复正常。
